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Nephron loop ; countercurrent mechanism

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1

The countercurrent mechanism consists of

"current" of water in one direction and "current" of NaCl moving in opposite direction

2

High sodium gradient maintained by

active transport of of Na and Cl in ascending limb

3

The nephron loop (loop of Henle) is located

between PCT and DCT of nephron

4

Function of nephron loop is

create concentration gradient thru use of countercurrent mechanism

5

The descending limb is also called _________ and is permeable to _____

thin segment; water

6

The ascending limb is also called ______ and actively transports ________

thick segement; electrolytes (Na,K, Cl) into interstitium

7

Isotonic fluid has

has the same salt concentration as cells and blood

8

Hypotonic solutions contain

less solute then blood does and causes water to leave the solution

9

Hypertonic solutions have

greater concentration of solutes than blood/body fluids

10

Solution moves enters the descending limb as a ______ mOsm ______ solution

300; isotonic

11

Solution moving thru the descending limb _____ moves out thru ____ to higher _____concentration in interstitium

water; aquaporins (water channels); solute

12

At the bottom of the nephron loop the concentration of the solution is up to ____ which is a _____solution

1200 mOsm; hypertonic

13

Solution moves up the ascending limb and active transport proteins also called called ______co-transport electrolytes into interstitium.

NKCC (Sodium, potassium, chloride)

14

The Ascending limb is not permeable to ____

water

15

The active transport proteins use ___; the solutes leaving ascending limb cause solution to be____ concentrated

ATP; less

16

Solution exiting nephron loop is ____ at ___ mOsm

hypotonic; 100

17

Aquaportins are____ and use ____movement

special protein channels; passive

18

Loop Diuretics block the ______

NKCC protein

19

Overall path through nephron loop (6 steps)

  1. 300 mOsm isotonic solution enters descending limb
  2. water moves out thru aquaporins
  3. bottom of nephron loop has 1200 mOsm hypertonic solution
  4. solution moves up ascending limb
  5. NKCC active transport proteins co-transport electrolytes back to interstitium
  6. solution leaving nephron loop is 100mOms hypotonic solution

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