MSK Dermatology terms
What are the layers of the skin?
Basale (Stem cells)
What are the epithelial junctions?
What is the the function of Tight junctions?
prevent paracellular movement
What ist he function/structure of adherens junctions?
CADherins with Ca-dependent adhesion
What are the structure/function of desmosome?
Cytokeratin intermediate filament
What is the structure/function of Gap Junction?
Proteins permit chemical communication between cells
What is the structure/function of Hemidesmosome?
Keratin into basal cells basement membrane +
integrins integrate Collagen + laminin in basement membrane
What is a macule
Flat lesion well circumscribed <1cm
What is a Patch
What is a papule
Elevated solid skin lesion <1cm
What is a plaque?
What is a vesicle
Small fulid containing blister <1cm
what is a bulla?
Large fluid containing blister >1 cm
what is a Pustule?
Vesicel with pus
what is a wheal
transient smooth papule or plaque
what is a scale?
Flaking off of coreneum
What is curst
What is hyperkeratosis?
thickening of corneum
What is parakeratosis?
Hyperkeratosis with retention of nuclei in stratum corneum
What is hypergranulosis?
increase thickness of granulosum
what is spongiosis?
epidermal accumulation of edematous fluid in Intercellular space
What is acantholysis?
Separation of epidermal cells
what is acanthosis?
Epidermal hyperplasia (spinosum)
What is albinism?
Normal melanocyte number but lack of melanin production (tyrosin transport or tyrosinase activity)
what is Melasma?
Hyperpigmentation with pregnancy
what is Vitiligo?
Ab against melanocytes causing depigmentation